If concomitant use is necessary, consider expanding the oxycodone and acetaminophen tablets dosage right until secure drug results are attained.
Advise people who're treated with oxycodone and acetaminophen tablets for more than a few months never to abruptly discontinue the medication. Recommend sufferers to consult with their medical doctor for your gradual discontinuation dose schedule to taper off the medication.
Take into account prescribing naloxone, depending on the affected person’s possibility components for overdose, including concomitant usage of CNS depressants, a history of opioid use disorder, or prior opioid overdose. The presence of possibility aspects for overdose must not protect against the correct management of ache in almost any specified client. Also consider prescribing naloxone if the affected person has house members (like small children) or other close contacts in danger for accidental ingestion or overdose.
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Make sure you know how to consider oxycodone/acetaminophen and what other medicines you'll want to avoid using with it. See also Drug Interactions part. Get health-related enable right away if any of those very serious Unwanted effects manifest: gradual/shallow breathing, abnormal lightheadedness, serious drowsiness/dizziness, trouble waking up.
Observe sufferers closely for respiratory melancholy, Primarily in the very first 24 to seventy two hours of initiating therapy and next dosage raises with oxycodone and acetaminophen tablets and change the dosage appropriately [see WARNINGS].
The causal part of opioids within the syndrome of hypogonadism is unknown since the numerous medical, Bodily, Way of life, and psychological stressors that get more info may impact gonadal hormone amounts haven't been sufficiently controlled for in experiments performed to this point [see ADVERSE REACTIONS].
Inform feminine patients of reproductive possible that oxycodone and acetaminophen tablets can cause fetal harm and to tell the Health care company of a recognised or suspected pregnancy [see PRECAUTIONS; PREGNANCY].
When taken with other central nervous procedure depressants, together with alcohol, using opioids may perhaps lead to coma or Dying.
Animal reproductive research haven't been conducted with oxycodone and acetaminophen tablets. Additionally it is not known irrespective of whether oxycodone and acetaminophen tablets could cause fetal hurt when administered into a Expecting woman or can have an affect on reproductive capacity.
Anaphylaxis: Anaphylaxis has been claimed with ingredients contained in oxycodone and acetaminophen tablets.
Serotonin syndrome: Situations of serotonin syndrome, a likely daily life-threatening problem, happen to be reported through concomitant usage of opioids with serotonergic drugs.
Oxycodone and acetaminophen tablets expose individuals and also other consumers to your dangers of opioid addiction, abuse, and misuse, which can cause overdose and Dying.
Suggest both sufferers and caregivers concerning the dangers of respiratory despair and sedation when PERCOCET is utilized with benzodiazepines or other CNS depressants (which includes Alcoholic beverages and illicit drugs). Suggest people never to push or work weighty equipment until eventually the results of concomitant use of the benzodiazepine or other CNS depressant have been established.